International Journal of Nutrition, Pharmacology, Neurological Diseases

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 11  |  Issue : 4  |  Page : 279--286

Preparation and evaluation of sustained release dosage forms for posttransplant care


Mullaicharam Bhupathyraaj1, Alka Ahuja1, Nirmala Halligudi1, Sushma Pole1, Hiba Salim Al Balushi1, Halima Ahmed Al Kaabi1, Saleem M Desai2 
1 College of Pharmacy, National University of science and Technology, Muscat, Sultanate of Oman
2 Rani Channamma University, Balagavi, Karnataka, India

Correspondence Address:
Mullaicharam Bhupathyraaj
National University of science and Technology, Muscat
Sultanate of Oman

Aim: The purpose of the study was to prepare and characterize microbeads for oral sustained release of tacrolimus. Design, methodology, and approach: Tacrolimus-based microbeads were developed by ionic gelation method. Xanthan gum, chitosan, and sodium alginate were used as polymers for aqueous internal phase using calcium chloride as a cross-linking agent. The microbeads were evaluated for morphologic features by scanning electron microscopy, percentage yield, drug entrapment, and in vitro drug release. Findings and implications: Microbeads were examined for the effects of various variables in formulation process. The cross-linking reaction between sodium alginate and calcium chloride for being converted into calcium alginate in the formulation process was used in the microencapsulation of tacrolimus core material. The results showed the compatibility of the drug with the polymers in the formulation as observed in Fourier-transform infrared spectroscopy studies. The formulated microbeads showed high percentage yield and drug entrapment efficacy and the optimized formulation showed a delayed release effect following zero-order mechanism of release. Conclusion: Ionotropic gelation method was found to be a suitable method for preparing tacrolimus microbead-sustained-release drug delivery system. Chitosan and xanthan gum polymers showed potential in aiding the formulation of sustained release tacrolimus microbeads. Xanthan gum is soluble in water and confers high viscosity at low concentrations. The molecular weight of xanthan gum is more than the chitosan polymer which leads to better sustained release of microbeads prepared with xanthan gum compared to chitosan microbeads. Both chitosan and xanthan gum microbeads followed zero-order-release kinetic models.


How to cite this article:
Bhupathyraaj M, Ahuja A, Halligudi N, Pole S, Al Balushi HS, Al Kaabi HA, Desai SM. Preparation and evaluation of sustained release dosage forms for posttransplant care.Int J Nutr Pharmacol Neurol Dis 2021;11:279-286


How to cite this URL:
Bhupathyraaj M, Ahuja A, Halligudi N, Pole S, Al Balushi HS, Al Kaabi HA, Desai SM. Preparation and evaluation of sustained release dosage forms for posttransplant care. Int J Nutr Pharmacol Neurol Dis [serial online] 2021 [cited 2021 Dec 3 ];11:279-286
Available from: https://www.ijnpnd.com/article.asp?issn=2231-0738;year=2021;volume=11;issue=4;spage=279;epage=286;aulast=Bhupathyraaj;type=0