Users Online: 342

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
     
ORIGINAL ARTICLE
Year : 2022  |  Volume : 12  |  Issue : 4  |  Page : 275-281

Actions of Caffeic Acid Loaded-Silver Nanoparticles on Blood Pressure, Oxidative Stress, and Antioxidants in Nitric Oxide Deficient Hypertensive Rats


Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India

Correspondence Address:
MSc, PhD Boobalan Raja
Associate Professor, Department of Biochemistry & Biotechnology, Annamalai University, Annnamalainagar-608 002, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijnpnd.ijnpnd_41_22

Rights and Permissions

Objectives: This study aimed to evaluate the antihypertensive and antioxidant potential of caffeic acid-loaded silver nanoparticles (CA-AgNPs) in Nω −Nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. Materials and methods: The rats have randomly divided into four groups, that is, Group I Control rats, Group II rats injected with CA-AgNPs, Group III L-NAME rats, and Group IV −L-NAME+ CA-AgNPs. Hypertension was induced in rats by oral administration of L-NAME (40 mg/kg body weight) dissolved in drinking water daily for 4 weeks. Rats were given intraperitoneal injection of CA-AgNPs (0.5 mg/kg/ml). Results: The results showed that L-NAME administration caused a sustained increase in blood pressure, levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), and a significant decrease in the activities of enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx), and levels of non-enzymatic antioxidants such as vitamin C and vitamin E in the tissues such as heart, aorta, liver, and kidney. Above pathological changes were considerably restored with the treatment of CA-AgNPs. Conclusions: The result confirms CA-AgNPs have enough potential to narrow down hypertension and oxidative stress in L-NAME hypertensive rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed214    
    Printed14    
    Emailed0    
    PDF Downloaded37    
    Comments [Add]    

Recommend this journal