Users Online: 11

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
Year : 2022  |  Volume : 12  |  Issue : 3  |  Page : 134-141

Potential Efficacy of Ocimum sanctum Hydro-Alcoholic Leaf Extract as an Adjuvant Role with Phenobarbital: Acute Models of Epilepsy on Mice

1 Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
2 Jai Institute of Pharmaceutical Sciences and Research, Gwalior, Madhya Pradesh, India

Correspondence Address:
Aman Shrivastava
Research Scholar, Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura (UP), 17km Stone, NH-2, Chaumuhan, India - 281406
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnpnd.ijnpnd_9_22

Rights and Permissions

Aim: In Ayurveda, various Ocimum species have therapeutic potential to enhance the therapeutic efficacy of some antiepileptic drugs in epilepsy. O. sanctum has two flavonoid compounds that are orientin and vicenin, and both are responsible for their anti-seizure properties in epilepsy. Material and Methods: The ultraviolet spectroscopy instrument was used to detect the absorbance of light by the active constituent present in the herbal extract at various concentrations. A turbidity meter was used to detect the amount of turbidity in the sample. Phenobarbital (PB 40 mg/kg, per oral [p.o.]) and O. sanctum hydroalcoholic leaf extract (OSHE 1000 mg/kg, p.o.) were administered every other day for 2 weeks in which two acute models, maximal electroshock and pentylenetetrazole (PTZ), models of epilepsy were used. Result: The outcome result data were statistically compared and showed Tukey test P < 0.05 of significant anticonvulsive activity as compared to control and standard (phenobarbitone). Conclusion: We have investigated the anti-seizure activity of PB with hydroalcoholic leaves extract of O. sanctum L. by using the electrically maximal electroshock seizure and chemically (PTZ) induced convulsion acute models of epilepsy on mice. As per the histopathological study, photomicrographs (×40) of mice brain tissue showed no neuronal degenerations or focal microglia sensitivities in OSHE + PB treated group. We concluded that the standard drug exhibits a synergistic effect with OSHE for the treatment of acute seizures in mice.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal