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Year : 2020  |  Volume : 10  |  Issue : 2  |  Page : 69-74

The Role of Phloridzin and its Possible Potential Therapeutic Effect on Parkinson’s Disease

1 Department of Biochemistry, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India
2 Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
3 Department of Pharmacology, JSS College of Pharmacy, Mysuru, Karnataka, India

Correspondence Address:
Preeja Prabhakar
Department of Biochemistry, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijnpnd.ijnpnd_80_19

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Parkinson’s disease (PD) is the second commonest neuro-degenerative disorder in the world and is complex in terms of its etio-pathological mechanisms, symptomatology, diagnosis and progression. Research on animal models, epidemiology, human postmortem analysis and genetic studies suggest that oxidative stress, mitochondrial dysfunction, neuro-inflammation, and derangements in neurochemical pathways regulating protein folding and aggregation, have a role in the etio-pathogenesis and progression PD. However, till date, the treatment options for PD including medication and surgical-interventions are only of symptomatic relief. There is no definite preventive or neuro-protective or disease-modifying cure currently available. The relevance of antioxidant molecules is considered as part of a novel research avenue tackling potential therapeutic adjuncts in the treatment of PD. The beneficial effects of naturally occurring dietary polyphenols provide promising perspectives and are of value in the quest of developing a novel generation of therapeutic agents capable of reducing neuro-inflammation and neuro-degeneration, thereby possibly delaying or preventing or halting the progression of PD. Phloridzin is a dihydrochalcone primarily present in unripe-apples (Malus sp., Rosaceae). There are many proposed mechanisms by which phloridzin mitigates the onset and decrease of the progression of neurodegenerative disorders such as PD. These protective actions of phloridzin include its antioxidant anti-neuro-inflammatory (by reducing pro-inflammatory and pro-apoptotic mediators) and modulation of gene expression including mitochondrial directed flavono-therapy. It is anticipated that further evidence in the efficacy of diet derived phenolic products like phloridzin could lend a novel perspective of the role of nutritional therapeutics in preventing the occurrence of neurodegenerative conditions including PD during the early stages and mitigate its progression in susceptible individuals.

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