Users Online: 714

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
Year : 2014  |  Volume : 4  |  Issue : 1  |  Page : 28-42

Neuropathology staging and treatment strategies of Alzheimer's disease: An update

Department of Pharmacology, School of Phamracy,Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow, Uttar Pradesh, India

Correspondence Address:
Ashutosh Kumar Yadav
Department of Pharmacology, School of Phamracy, Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow - 227 105, Uttar Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.124612

Rights and Permissions

Alzheimer's disease (AD) is a devastating neurodegenerative disorder manifested by deterioration in memory and cognition, impairment in performing activities of daily living. The pathological hallmark of AD is widespread neuritic plaques which are accumulation of amyloid beta protein and neurofibrillary tangles. This review has been done on various causes due to neurofibrillary tangles, senile plaque, gene, and different factors involved in aging and injury. Treatment of AD targeting toward cholinergic deficiency, oxidative stress, protein oxidation, protein nitration, tau and tangles formation, mitochondrial dysfunction, and inflammation. Pharmaceutical therapies include cholinesterase inhibitors, memantine, antihypertensive drugs, anti-inflammatory drugs, secretase inhibitors, brain-derived neurotrophic factor, and immunization. Nutrition and natural therapies, various vitamins and minerals also play a role in treatment. Approaches that target several dysfunctions simultaneously and that emphasize nutritional, natural, and stimulatory therapies may offer the most benefit at this time.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded324    
    Comments [Add]    
    Cited by others 2    

Recommend this journal