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Year : 2013  |  Volume : 3  |  Issue : 3  |  Page : 206-218

Silibinin: A promising anti-neoplastic agent for the future? A critical reappraisal

1 Clinical Pharmacology, Dr. Naveen's Care and Cure Clinic, Chandigarh, India
2 Gynecology and obstetrics, Dr. Naveen's Care and Cure Clinic, Chandigarh, India
3 Department of Internal Medicine, PGIMER, Chandigarh, India
4 Dentistry Dr. Naveen's Care and Cure Clinic, Chandigarh, India

Correspondence Address:
Naveen Chhabra
W.S. 334, Basti Sheikh, Jalandhar, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.114836

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Silibinin, a flavonolignan, is the major active component of the milk thistle plant (Silybummarianum). Silibinin have been used as medicinal herbs in the treatment of liver cirrhosis, chronic hepatitis, and gallbladder disorders. Numerous studies suggest that silibinin is a powerful antioxidant and has hepatoprotective properties and anti-neoplastic effects against various carcinoma cells. Silibinin had shown promising anti-neoplastic effects against skin, breast, lung, pancreatic, colon, cervical, prostate, bladder, and kidney carcinomas in various in vitro/in vivo and preclinical studies. Treatment claims also include lowering cholesterol levels, reducing insulin resistance, and anti-viral activity. Other reported uses of milk thistle in folk medicine include as a treatment for malarial fever, bronchitis, peritonitis, uterine congestion, varicose veins, and as a milk production stimulant for nursing mothers. The aim of the present article is to review and summarize the pharmacokinetics, physical properties, the mechanism of action, and the effectiveness and safety of silibininin various cancers/neoplasms.

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