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Year : 2013  |  Volume : 3  |  Issue : 1  |  Page : 34-38

Comparing the efficacy of carbamazepine, gabapentin and lamotrigine in chronic constriction injury model of neuropathic pain in rats

1 Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka, India
2 Melaka Manipal Medical College, Manipal, Karnataka, India
3 International Center, Manipal University, Manipal, Karnataka, India

Correspondence Address:
Bharti Chogtu
Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka-576 104
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.106987

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Context: Anti-epileptics are used in the treatment of neuropathic pain. Newer anti- epileptics with improved safety profile are being used in neuropathic pain. The animal models of neuropathic pain have helped to find newer drugs for this condition. As the efficacy of these drugs is modest, there is always a need to compare the efficacy of newer anti-epileptics with conventional drugs in this condition. Aims: The aim of this study was to compare the efficacy of anti-epileptics in neuropathic pain induced by chronic constriction injury. Settings and Design: It was a randomised, prospective study. Materials and Methods: The rats were divided into four groups. The first three groups were administered each of carbamazepine, gabapentin and lamotrigine respectively and the fourth group acted as control. Assessment was started on day five of surgery by hot plate method and Randall Selitto test. Statistical Analysis Used: Statistical analysis was done by one way analysis of variance followed by posthoc test. Results: In mechanical allodynia rats treated with lamotrigine and gabapentin (P = 0.001) showed a significant increase in mechanical threshold whereas in thermal hyperalgesia, it was the carbamazepine (P = 0.027) which was superior to other two drugs. Conclusions: Lamotrigine and gabapentin are efficacious in mechanical allodynia whereas carbamazepine is superior in thermal hyperalgesia. This shows that effect of drugs vary in different behavioral tests. So, the choice of treatment in different types of neuropathic pain can vary.

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