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Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 8-15

Capsaicin: A promising therapy - A critical reappraisal

Department of Pharmacology, J L N Medical College and Hospital, Ajmer, Rajasthan, India

Correspondence Address:
Naveen Chhabra
c/o Dr. M. L. Aseri, I/3 J L N Medical College and Hospital Campus, Ajmer, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.93124

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Capsaicin, major capsainoid, derived from dried fruit of chilli pepper, is synthesized in the interlocular septa of chilli peppers by addition of a branched-chain fatty acid to vanillylamine. An extensive, although largely forgotten, literature addresses the utility of the capsaicin therapy as either adjunctive or main treatment strategy for a number of diseases. Topical capsaicin has been shown to improve the outcome in neuropathic and musculoskeletal pain, post herpetic neuralgia, arthritic pain, burning mouth syndrome, pain due to fibromyalgia, psoriatic disorder, burning mouth syndrome, various allergic disorders, and as intranasally for cluster headache. Capsaicin is under development therapy for various diseases, it may develop as a new treatment therapy for a number of diseases in near future. However, studies with systemic ingestion are limited and have been shown gastrointestinal adverse effects, which may be major limitations to systemic capsaicin therapy.

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