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Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 57-60

Folate and vitamin B12 deficiency is associated with colorectal cancer in Jordan

1 Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman
2 Princess Al-Johara Al Ibrahim for Cancer Research, King Saud University, Saudi Arabia
3 Department of Data Management, Jordan Cancer Registry, Ministry of Health, Amman, Jordan
4 Department of Epidemiology, High Institute of Public Health, Alexandria University, Egypt
5 Department of Public Health, Faculty of Medicine, Jordan University for Science and Technology, Jordan

Correspondence Address:
Mostafa I Waly
Department of Food Science and Nutrition, P.O. Box 34, Al-Koud-123, Sultan Qaboos University, Muscat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0738.93127

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Aim: This case-control study was aimed to evaluate the folate and vitamin B12 status among patients recently diagnosed with colorectal cancer (CRC), in Jordan. Materials and Methods: The study involved 220 recently diagnosed Jordanian CRC patients and 220 age- and gender-matched healthy controls. The dietary intake and biochemical assessment of folate and vitamin B12 were determined for all the study participants. Results: The CRC patients had lower daily intake and serum levels of both folate (189.28 ± 11.78 μg/day and 6.6 ± 1.3 μg/l, respectively) and vitamin B12 (1.09 ± 0.4 μg/day and 233.7 ± 17.9 pg/ml, respectively) as compared to their matched control groups (212.58 ± 13.18 μg/day and 16.2 ± 2.8 μg/l, respectively, for folate) and (2.49 ± 1.3 μg/day and 458.9 ± 30.9 pg/ml, respectively, for vitamin B12). Conclusion: The CRC Jordanian patients who participated in this study had a low status of folate and vitamin B12, and a well-established etiological factor for CRC.

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